Diagnosis and treatment of primary gastric non-Hodgkin's lymphoma: analysis of 157 patients / 中华预防医学杂志

<p><b>OBJECTIVE</b>To seek the optimum treatment for patients with primary gastric non-Hodgkin's lymphoma and factors associated with prognosis.</p><p><b>METHODS</b>A retrospective study was conducted on 157 primary gastric non-Hodgkin's lymphoma patients who had received operation for 45 years.</p><p><b>RESULTS</b>The X-ray diagnosis rate was 39.4% before operation. The diagnosis rate by gastroscopy was 52.7%. Among the 157 patients, 32 belonged to stage I(E), 40 stage II(E), 29 stage III(E), and 56 stage IV(E). All of the patients were received chemotherapy or radiation. The 3-, 5-, 10-, 15-year survival rates were 51.1% (69/135), 42.3% (55/130), 20.7% (23/111), and 13.5% (14/104).</p><p><b>CONCLUSIONS</b>The 3-, 5-year survival rates in stage I(E) and stage II(E) were 2 to 5 times higher than those in stage III(E) and IV(E) (P < 0.01). The 3-, 5-year survival rates of primary gastric non-Hodgkin's lymphoma were 60.2% (65/108) and 50.0% (52/104) respectively. The prognosis was better than the 5-year survival rate of gastric cancer patients with D(2) lymphodenectomy (33.3%). Early diagnosis and treatment are effective to prevent complications, enhance quality of patient's life, and prolong the survival.</p>

116 multiple primary cancers in the digestive system / 中华肿瘤杂志

<p><b>OBJECTIVE</b>To study the clinical characteristics, diagnosis, strategy of treatment and prognosis of multiple primary cancers in the digestive system.</p><p><b>METHODS</b>All malignant lesions in the digestive system encountered in the past 10 years were analysed by a computer software.</p><p><b>RESULTS</b>116 cases of multiple cancers were observed with an incidence of 1.74%. Male to female ratio was 2.7:1. There were 62 synchronous carcinomas and 54 metachronous ones. In decreasing sequence, they were: colon > stomach > rectum > liver. The 1-, 3-and 5-year survival rates of the synchronous ones were 42.3%, 23.1% and 11.5%. Those of metachronous ones were 95.2%, 85.7% and 76.2%.</p><p><b>CONCLUSION</b>High frequency of multiple primary cancers is found in the colon, especially over the right side. Metachronous carcinomas usually give better prognosis than the synchronous ones. The longer the interval between the development of the two primary lesions, the better the prognosis. Multiple cancers of the colon have satisfactory prognosis. The key to improve the treatment is to be vigilant against lesions in the digestive tract so as to arrive at a timely diagnosis and treatment. The strategy of combining radical treatment with immuno-supportive therapy is advocated.</p>

Primary colorectal non-Hodgkin′s lymphoma: analysis of 68 cases / 中国普通外科杂志

Objective To sum up our experience on the diagnosis and treatment of primary colorectal non-Hodgkin′s lymphoma (PCNHL). Methods Clinical data of 68 PCNHL cases admitted during the past 33 years in Tianjin Cancer Hospital were analyzed retrospectively. Results The median age was 46 years with male to female ratio of 1.8∶1. Main symptoms include abdominal pain, mass, diarrhea, weight loss, bloody stool, nausea-vomiting. The average diameter of the tumor was 8.3 cm. 43% tumors were located in the cecum. Thirty-three patients were in stage ⅠE, 18 in stage ⅡE, 6 in stage ⅢE, 11 in stage ⅣE. Fourty-two patients received radical resection, 26 did palliative resection. 1-, 3- and 5-year survival rate were 63%、 47%、 44%, respectively. Conclusion PCNHL is often seen in young adults with a female preponderence. Surgery and tumor stage were independent prognostic factors.

The diagnosis and surgical treatment of nonfunctional islet cell tumors of the pancreas / 中国普通外科杂志

ObjectiveTo review the experience on the diagnosis and surgical treatment nonfunctional islet cell tumors (NIT) of the pancreas. MethodsData of 32 NIT patients of the pancreas during the past 46 years in Tianjin Cancer Hospital were analyzed retrospectively.ResultThe average of patients was 32 years old,with female to male ratio of 2.6∶1. The major symptoms included abdominal mass, bellyache, abdominal distension, obstructive jaundice, and back pain. The average diameter of the tumor was 9 cm. Tumors were single in 94% of all cases and multiple in 6%. Tumors located in the head of pancreas in 47% of all cases, in the body in 16%, in the tail in 31%. Tumors were malignant in 69%(22/32) and benign in 31% (10/32 ) .Pancreaticoduodenectomy was performed in 22%, resection of the spleen and pancreatic body-tail in 34%, resection of the body and tail of the pancreas in 16%, biopsy and biliary-enterostomy in 13%, tumor enucleation in 9%, biopsy only in 6%. The main postoperative complications were pancreatic fistulae (25%) and wound infection (9%). The 1? 3 and 5-year survival rates of malignant patients were 90%, 80% and 69%, respectively.ConclusionNIT is often single and large at the time when the patients sought medical consultation. The postoperative prognosis of patients with malignant tumor is favorable.